The Macroautophagy Machinery in MHC Restricted Antigen Presentation
نویسندگان
چکیده
Autophagy-related (ATG) gene products regulate macroautophagy, LC3-associated phagocytosis (LAP) and LC3-dependent extracellular vesicle loading secretion (LDELS). These processes also influence antigen processing for presentation on major histocompatibility complex (MHC) molecules to T cells. Here, I summarize how these different pathways use the macroautophagy machinery, contribute MHC class II restricted autoimmunity, tumor immunology immune control of infectious diseases. Targeting should allow regulation intracellular cells modulate protective pathological responses.
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2021
ISSN: ['1664-3224']
DOI: https://doi.org/10.3389/fimmu.2021.628429